IQSEC1

Across TCGA pan-cancer cohorts, IQSEC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IQSEC1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IQSEC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IQSEC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where IQSEC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.804	0.373	<.001	34	view →
UCEC	OS	Median	II,III,IV	0.628	1.000	.013	12	view →
PDAC	DFS	Median	II,III,IV	0.313	0.444	.037	6	view →
LSCC	DFS	Quartile	II,III,IV	0.608	1.000	.019	5	view →
HNSC	DFS	Median	II,III,IV	0.557	0.745	.023	4	view →
LUAD	DFS	Tertile	All	0.760	0.547	.045	3	view →
GBM	DFS	Median	All	0.817	0.678	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IQSEC1–CCRCC (DFS)

Open the CCRCC breakdown →