IQSEC1

Across TCGA patient cohorts, IQSEC1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,702 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IQSEC1-associated genes across cancer lineages are EMCN, SEPTIN4, and FHL5. Each is linked with IQSEC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both IQSEC1-to-partner and partner-to-IQSEC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC1 versus EMCN in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC1→partner) and Y-score (partner→IQSEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMCN →	+1.371	+0.321	<.001	<.001	3	7
GBM	SEPTIN4 →	+0.796	+0.415	<.001	<.001	3	6
CCRCC	FHL5 →	+0.947	+0.213	<.001	<.001	3	6
CCRCC	PDE1A →	+0.984	+0.231	<.001	<.001	3	6
UCEC	AOC3 →	+1.079	+0.348	<.001	<.001	3	6
GBM	ATP1A2 →	+1.409	+0.328	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,702 associations by consensus.

IQSEC1 vs EMCN — UCEC

Explore this scatter interactively →