IQSEC1

Across TCGA patient cohorts, IQSEC1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQSEC1-associated genes across cancer lineages are CDK1, mTOR_pS2448, and PCNA. Each is linked with IQSEC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IQSEC1-to-partner and partner-to-IQSEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by IQSEC1-low versus IQSEC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC1→partner) and Y-score (partner→IQSEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDK1 →	+0.237	+2.330	.003	.020	3	3
UCEC	mTOR_pS2448 →	-0.145	-2.050	.001	.001	3	3
UCEC	PCNA →	+0.221	+1.807	<.001	.003	3	3
UCEC	Rab25 →	-0.406	-2.906	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.358	-1.893	<.001	<.001	3	2
SKCM	YAP_pS127 →	-0.374	-3.000	.044	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

CDK1 by IQSEC1 expression — COAD

Explore this box plot interactively →