IQSEC1

Across TCGA cell cohorts, IQSEC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQSEC1-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Negative regulation of calcium ion export across plasma membrane, and Negative regulation of hippo signaling. Each is linked with IQSEC1 in more than 13 cancer types. Because this analysis shows association rather than direction, both IQSEC1-to-partner and partner-to-IQSEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by IQSEC1-low versus IQSEC1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC1→partner) and Y-score (partner→IQSEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.101	+1.211	.001	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.104	+1.359	<.001	<.001	3	14
SOFT_TISSUE	Negative regulation of hippo signaling →	+0.104	+1.155	<.001	<.001	3	13
STOMACH	Golgi vesicle transport →	+0.094	+1.138	<.001	.003	3	13
STOMACH	Regulation of myoblast fusion →	+0.140	+1.466	<.001	.004	3	13
STOMACH	Vacuole organization →	+0.062	+1.148	<.001	.007	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,263 associations by consensus.

Viral translational termination-reinitiation by IQSEC1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →