IQSEC1

Across TCGA cell cohorts, IQSEC1 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQSEC1-associated genes across cancer lineages are KRTAP10-1, FAM205A, and KRTAP5-6. Each is linked with IQSEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQSEC1-to-partner and partner-to-IQSEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-1 grouped by IQSEC1-low versus IQSEC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC1→partner) and Y-score (partner→IQSEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	2
OVARY	FAM205A →	+0.037	+2.866	.001	.008	3	2
OVARY	KRTAP5-6 →	+0.087	+3.022	.007	.005	3	2
CNS	CT45A9 →	+0.036	+5.754	<.001	.002	3	2
BLOOD_Lymphoma	CSTL1 →	+0.535	+4.867	<.001	.009	3	2
BLOOD_Myeloma	GPR12 →	+0.030	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

KRTAP10-1 by IQSEC1 expression — SOFT_TISSUE

Explore this box plot interactively →