IQGAP2

Across TCGA pan-cancer cohorts, IQGAP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IQGAP2 data layer compared with 19 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IQGAP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IQGAP2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where IQGAP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.614	0.281	<.001	95	view →
CCRCC	OS	Median	II,III,IV	0.954	0.682	.001	36	view →
HNSC	DFS	Quartile	All	0.906	1.000	.027	3	view →
LSCC	OS	Median	III,IV	0.951	0.758	.024	2	view →
GBM	DFS	Tertile	All	0.234	0.424	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IQGAP2–PDAC (OS)

Open the PDAC breakdown →