IQGAP2

Across TCGA patient cohorts, IQGAP2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,977 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IQGAP2-associated genes across cancer lineages are SLC40A1, PFDN4, and TRIB3. Each is linked with IQGAP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IQGAP2-to-partner and partner-to-IQGAP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQGAP2 versus SLC40A1 in UCEC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP2→partner) and Y-score (partner→IQGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC40A1 →	+1.172	+0.502	<.001	<.001	3	8
BRCA	PFDN4 →	-0.762	-0.900	<.001	<.001	3	6
UCEC	TRIB3 →	-1.037	-0.633	.001	<.001	3	6
HNSC	SLC2A1 →	-1.443	-0.411	<.001	<.001	3	6
UCEC	MTARC2 →	+0.925	+0.741	<.001	<.001	3	6
BRCA	CSE1L →	-0.543	-0.594	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,977 associations by consensus.

IQGAP2 vs SLC40A1 — UCEC

Explore this scatter interactively →