IQGAP2

Across TCGA patient cohorts, IQGAP2 mutation is significantly associated with the RNA expression of many other genes, with 5,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQGAP2-associated genes across cancer lineages are EME1, SOD1, and MIS18A. Each is linked with IQGAP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both IQGAP2-to-partner and partner-to-IQGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by IQGAP2-low versus IQGAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP2→partner) and Y-score (partner→IQGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.450	+1.747	<.001	<.001	3	5
LUSC	SOD1 →	+0.495	+2.724	.001	.003	3	5
UCEC	MIS18A →	+0.371	+1.169	.003	.005	3	4
UCEC	SPC24 →	+0.483	+1.584	.001	<.001	3	4
UCEC	PBK →	+0.755	+2.081	<.001	<.001	3	4
UCEC	NPRL2 →	+0.235	+3.439	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,280 associations by consensus.

EME1 by IQGAP2 expression — UCEC

Explore this box plot interactively →