IQGAP2

Across TCGA patient cohorts, IQGAP2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQGAP2-associated genes across cancer lineages are Rictor_pT1135, PDCD4, and CD31. Each is linked with IQGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQGAP2-to-partner and partner-to-IQGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by IQGAP2-low versus IQGAP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP2→partner) and Y-score (partner→IQGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Rictor_pT1135 →	-0.116	-3.312	.046	.010	3	2
COAD	PDCD4 →	-0.433	-2.991	.047	.036	3	2
COAD	CD31 →	+0.211	+3.008	.017	.019	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.299	.001	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.170	-2.058	<.001	<.001	3	2
UCEC	Ku80 →	+0.148	+1.160	.020	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Rictor_pT1135 by IQGAP2 expression — LUSC

Explore this box plot interactively →