IQGAP2

Across TCGA cell cohorts, IQGAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,000 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible IQGAP2-associated GO terms across cancer lineages are Thrombin-activated receptor signaling pathway, Purine nucleoside triphosphate biosynthetic process, and Purine ribonucleoside triphosphate biosynthetic process. Each is linked with IQGAP2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IQGAP2-to-partner and partner-to-IQGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thrombin-activated receptor signaling pathway grouped by IQGAP2-low versus IQGAP2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP2→partner) and Y-score (partner→IQGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Thrombin-activated receptor signaling pathway →	+0.773	+1.090	.004	.003	3	8
OVARY	Purine nucleoside triphosphate biosynthetic process →	+0.085	+1.807	.003	<.001	3	8
OVARY	Purine ribonucleoside triphosphate biosynthetic process →	+0.085	+1.807	.003	<.001	3	8
OESOPHAGUS	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.111	+1.474	<.001	.005	3	8
OVARY	Proton motive force-driven ATP synthesis →	+0.092	+1.698	<.001	<.001	3	8
KIDNEY	Aerobic electron transport chain →	+0.076	+1.826	.002	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,000 associations by consensus.

Thrombin-activated receptor signaling pathway by IQGAP2 expression — LUNG_SCLC

Explore this box plot interactively →