IQGAP1

Across TCGA pan-cancer cohorts, IQGAP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IQGAP1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IQGAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IQGAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where IQGAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.469	0.946	.004	16	view →
LUAD	DFS	Median	II,III,IV	0.287	0.666	.002	16	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
GBM	DFS	Median	All	0.673	0.822	.013	4	view →
HNSC	DFS	Tertile	III,IV	0.874	0.652	.034	2	view →
LSCC	OS	Median	All	0.763	0.882	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IQGAP1–CCRCC (DFS)

Open the CCRCC breakdown →