IQGAP1

Across TCGA patient cohorts, IQGAP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,580 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IQGAP1-associated proteins across cancer lineages are AKAP13_S983, IQGAP1_S330, and AKAP13_T953. Each is linked with IQGAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IQGAP1-to-partner and partner-to-IQGAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQGAP1 versus AKAP13_S983 in PDAC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP1→partner) and Y-score (partner→IQGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AKAP13_S983 →	+0.579	+0.378	<.001	<.001	3	5
PDAC	IQGAP1_S330 →	+0.868	+0.498	<.001	<.001	3	5
COAD	AKAP13_T953 →	+0.440	+0.484	.002	<.001	3	5
PDAC	PAIP2B →	-0.855	-0.452	<.001	<.001	3	5
GBM	AKAP13 →	+0.315	+0.530	<.001	<.001	3	5
GBM	LMNA_S390 →	+0.489	+0.606	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,580 associations by consensus.

IQGAP1 vs AKAP13_S983 — PDAC

Explore this scatter interactively →