IQGAP1

Across TCGA patient cohorts, IQGAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,451 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IQGAP1-associated genes across cancer lineages are SCML2, SQOR, and ANXA2. Each is linked with IQGAP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both IQGAP1-to-partner and partner-to-IQGAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQGAP1 versus SCML2 in LSCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP1→partner) and Y-score (partner→IQGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCML2 →	-1.202	-0.289	<.001	<.001	3	7
GBM	SQOR →	+0.819	+0.559	<.001	<.001	3	6
GBM	ANXA2 →	+1.228	+0.558	<.001	<.001	3	6
GBM	LACTB →	+0.462	+0.625	<.001	<.001	3	5
GBM	CAV1 →	+1.817	+0.548	<.001	<.001	3	5
BRCA	TEP1 →	+0.724	+0.250	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,451 associations by consensus.

IQGAP1 vs SCML2 — LSCC

Explore this scatter interactively →