IQGAP1

Across TCGA patient cohorts, IQGAP1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQGAP1-associated genes across cancer lineages are ACC_pS79, Notch1, and Rad50. Each is linked with IQGAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IQGAP1-to-partner and partner-to-IQGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by IQGAP1-low versus IQGAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP1→partner) and Y-score (partner→IQGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.268	+1.125	.010	.033	3	2
UCEC	Notch1 →	+0.110	+1.424	.009	.027	3	2
UCEC	Rad50 →	-0.172	-1.125	.018	.033	3	2
UCEC	Shc_pY317 →	-0.185	-1.999	<.001	<.001	3	2
UCEC	ATM →	-0.489	-1.986	<.001	.008	3	2
UCEC	4E-BP1 →	+0.407	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ACC_pS79 by IQGAP1 expression — UCEC

Explore this box plot interactively →