IQGAP1

Across TCGA cell cohorts, IQGAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,021 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IQGAP1-associated GO terms across cancer lineages are Negative regulation of actin filament depolymerization, Actin filament organization, and Negative regulation of protein depolymerization. Each is linked with IQGAP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IQGAP1-to-partner and partner-to-IQGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament depolymerization grouped by IQGAP1-low versus IQGAP1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP1→partner) and Y-score (partner→IQGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of actin filament depolymerization →	+0.208	+1.281	<.001	<.001	3	13
BONE	Actin filament organization →	+0.138	+1.049	<.001	<.001	3	12
BONE	Negative regulation of protein depolymerization →	+0.099	+0.684	<.001	.004	3	12
STOMACH	Positive regulation of myoblast fusion →	+0.300	+0.950	<.001	<.001	3	12
STOMACH	Negative regulation of supramolecular fiber organization →	+0.086	+0.920	<.001	<.001	3	12
STOMACH	Positive regulation of protein localization to cell periphery →	+0.106	+1.112	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,021 associations by consensus.

Negative regulation of actin filament depolymerization by IQGAP1 expression — STOMACH

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