IQGAP1

Across TCGA cell cohorts, IQGAP1 mutation is significantly associated with the RNA expression of many other genes, with 478 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQGAP1-associated genes across cancer lineages are ADAM7, FAM236A, and POTEB3. Each is linked with IQGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQGAP1-to-partner and partner-to-IQGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by IQGAP1-low versus IQGAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQGAP1→partner) and Y-score (partner→IQGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.002	+2.345	<.001	.007	3	2
BLOOD_Leukemia	FAM236A →	+0.126	+5.269	<.001	<.001	3	2
LIVER	POTEB3 →	+0.012	+3.977	<.001	.006	3	1
BONE	WFDC10B →	+0.365	+4.307	<.001	.004	3	1
BONE	RNASE9 →	+0.005	+4.169	<.001	.008	3	1
BONE	LRIT2 →	+0.005	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 478 associations by consensus.

ADAM7 by IQGAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →