IQCN

Across TCGA patient cohorts, IQCN RNA expression is significantly associated with the protein abundance of many other proteins, with 10,960 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IQCN-associated proteins across cancer lineages are RRBP1_T275, RPL5, and KANK2. Each is linked with IQCN in more than 5 cancer types. Because this analysis shows association rather than direction, both IQCN-to-partner and partner-to-IQCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQCN versus RRBP1_T275 in CCRCC, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCN→partner) and Y-score (partner→IQCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RRBP1_T275 →	-0.691	-0.452	.002	.001	3	6
BRCA	RPL5 →	-0.246	-0.749	<.001	<.001	3	5
OV	KANK2 →	+0.395	+1.544	.001	<.001	3	5
PDAC	PLAC9 →	+0.643	+0.332	.006	.004	3	5
LUAD	YME1L1 →	-0.332	-0.665	<.001	<.001	3	5
LUAD	NAA15 →	-0.256	-0.659	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,960 associations by consensus.

IQCN vs RRBP1_T275 — CCRCC

Explore this scatter interactively →