IQCN

Across TCGA patient cohorts, IQCN mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCN-associated genes across cancer lineages are MEK1, Rad50, and FASN. Each is linked with IQCN in more than 2 cancer types. Because this analysis shows association rather than direction, both IQCN-to-partner and partner-to-IQCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by IQCN-low versus IQCN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCN→partner) and Y-score (partner→IQCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.342	+2.662	<.001	<.001	3	3
UCEC	Rad50 →	-0.177	-1.794	.009	.024	3	3
COAD	FASN →	+0.607	+2.815	.004	.036	2	3
COAD	GAPDH →	+0.848	+2.815	.002	.036	3	2
COAD	PCNA →	+0.335	+2.815	.013	.036	3	2
UCEC	A-Raf_pS299 →	-0.086	-1.321	.010	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by IQCN expression — UCEC

Explore this box plot interactively →