IQCN

Across TCGA cell cohorts, IQCN mutation is significantly associated with the RNA expression of many other genes, with 1,141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCN-associated genes across cancer lineages are UBE2D3, AKAP3, and SLC39A7. Each is linked with IQCN in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCN-to-partner and partner-to-IQCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2D3 grouped by IQCN-low versus IQCN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCN→partner) and Y-score (partner→IQCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBE2D3 →	+0.489	+3.237	.001	.003	3	2
LARGE_INTESTINE	AKAP3 →	+0.811	+3.169	<.001	.009	3	2
LARGE_INTESTINE	SLC39A7 →	+0.599	+2.526	.002	.002	3	2
LARGE_INTESTINE	TMEM241 →	+0.644	+2.502	.001	.005	3	2
LARGE_INTESTINE	AP1AR →	+0.562	+2.502	.006	.005	3	2
BLOOD_Leukemia	BBS7 →	+0.708	+3.199	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,141 associations by consensus.

UBE2D3 by IQCN expression — LARGE_INTESTINE

Explore this box plot interactively →