IQCH-AS1

Across TCGA pan-cancer cohorts, IQCH-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IQCH-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IQCH-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IQCH-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.

KIRP, READ, and LIHC are the cancer types where IQCH-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.978	0.785	.004	68	view →
READ	OS	Median	II,III,IV	0.806	0.308	<.001	57	view →
LIHC	OS	Median	II,III,IV	0.742	0.496	<.001	43	view →
HNSC	OS	Tertile	IV	0.521	0.298	.003	32	view →
UCS	DFS	Median	IV	0.909	0.416	.008	26	view →
LUAD	DFS	Quartile	II,III,IV	0.296	0.567	.021	16	view →
CHOL	OS	Quartile	All	0.892	0.185	.010	15	view →
BLCA	DFS	Median	All	0.400	0.286	.020	15	view →
ACC	OS	Quartile	IV	0.837	0.426	.006	9	view →
KIRC	DFS	Tertile	IV	0.629	0.287	.017	6	view →
MESO	OS	Quartile	IV	0.926	0.327	.031	6	view →
THYM	OS	Median	All	0.746	0.983	.009	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IQCH-AS1–KIRP (DFS)

Open the KIRP breakdown →