IQCG

Across TCGA patient cohorts, IQCG mutation is significantly associated with the RNA expression of many other genes, with 3,410 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCG-associated genes across cancer lineages are MIR6853, OR4A18P, and RNU7-52P. Each is linked with IQCG in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCG-to-partner and partner-to-IQCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by IQCG-low versus IQCG-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCG→partner) and Y-score (partner→IQCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.181	+7.473	<.001	.007	3	2
CESC	OR4A18P →	+0.034	+4.984	<.001	.003	3	2
PRAD	RNU7-52P →	+0.503	+7.939	<.001	.008	3	2
UCEC	ZNHIT3 →	+0.474	+3.191	<.001	<.001	3	2
UCEC	PIGW →	+0.620	+3.180	<.001	<.001	3	2
UCEC	CCDC15 →	+0.317	+1.748	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,410 associations by consensus.

MIR6853 by IQCG expression — BRCA

Explore this box plot interactively →