IQCG

Across TCGA cell cohorts, IQCG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,974 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IQCG-associated GO terms across cancer lineages are Protein localization to cilium, Protein localization to ciliary transition zone, and Regulation of organelle assembly. Each is linked with IQCG in more than 11 cancer types. Because this analysis shows association rather than direction, both IQCG-to-partner and partner-to-IQCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cilium grouped by IQCG-low versus IQCG-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCG→partner) and Y-score (partner→IQCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein localization to cilium →	+0.067	+0.826	<.001	<.001	3	12
PANCREAS	Protein localization to ciliary transition zone →	+0.080	+0.756	<.001	<.001	3	11
LUNG_SCLC	Regulation of organelle assembly →	+0.054	+1.243	<.001	<.001	3	10
OESOPHAGUS	Transport along microtubule →	+0.048	+0.800	<.001	.001	3	10
OESOPHAGUS	Microtubule-based transport →	+0.047	+0.905	<.001	<.001	3	10
PANCREAS	Protein localization to ciliary membrane →	+0.089	+0.851	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,974 associations by consensus.

Protein localization to cilium by IQCG expression — PANCREAS

Explore this box plot interactively →