IQCG

Across TCGA cell cohorts, IQCG mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IQCG-associated genes across cancer lineages are GIMAP7 and CR1. Each is linked with IQCG in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCG-to-partner and partner-to-IQCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMAP7 grouped by IQCG-low versus IQCG-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCG→partner) and Y-score (partner→IQCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GIMAP7 →	+0.054	+4.169	<.001	.008	3	1
CNS	CR1 →	+0.292	+4.070	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GIMAP7 by IQCG expression — CNS

Explore this box plot interactively →