IQCG

Across TCGA cell cohorts, IQCG mutation is significantly associated with the mutation status of many other genes, with 1,931 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCG-associated genes across cancer lineages are BEST2, LAMA3, and ITGA2B. Each is linked with IQCG in more than 3 cancer types. Because this analysis shows association rather than direction, both IQCG-to-partner and partner-to-IQCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEST2 grouped by IQCG-low versus IQCG-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCG→partner) and Y-score (partner→IQCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BEST2 →	+5.277	+4.459	.005	.005	1	4
BLOOD_Leukemia	LAMA3 →	+2.779	+4.326	.006	.006	1	3
LARGE_INTESTINE	ITGA2B →	+2.781	+4.504	<.001	<.001	1	3
LARGE_INTESTINE	TMEM260 →	+2.652	+3.471	.004	.004	1	3
BLOOD_Leukemia	FREM1 →	+2.572	+4.129	.009	.009	1	3
LARGE_INTESTINE	C15orf39 →	+2.289	+3.182	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,931 associations by consensus.

BEST2 by IQCG expression — CNS

Explore this box plot interactively →