Across TCGA pan-cancer cohorts, IQCF6 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IQCF6’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IQCF6 RNA is repressed in tumor relative to normal tissue. In most cancer types IQCF6 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, UCEC, and KIRP are the cancer types where IQCF6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCF6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.