Across TCGA pan-cancer cohorts, IQCF4P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IQCF4P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IQCF4P RNA is repressed in tumor relative to normal tissue. In most cancer types IQCF4P is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, UCEC, and KIRP are the cancer types where IQCF4P tumor–normal differential expression is most reproducible.