IQCF3

Across TCGA patient cohorts, IQCF3 mutation is significantly associated with the RNA expression of many other genes, with 434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCF3-associated genes across cancer lineages are LGALS13, FBXO3-DT, and UBE2Q2P11. Each is linked with IQCF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCF3-to-partner and partner-to-IQCF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS13 grouped by IQCF3-low versus IQCF3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCF3→partner) and Y-score (partner→IQCF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LGALS13 →	+0.046	+3.069	<.001	.009	3	2
SKCM	FBXO3-DT →	+0.093	+3.352	.001	<.001	3	2
SKCM	UBE2Q2P11 →	+0.272	+2.845	.001	.002	3	2
UCEC	MIR6075 →	+0.333	+3.152	.001	<.001	3	2
SKCM	FUT5 →	+0.046	+2.678	.008	.004	3	1
LUSC	OR7E149P →	+0.068	+5.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 434 associations by consensus.

LGALS13 by IQCF3 expression — SKCM

Explore this box plot interactively →