IQCF3

Across TCGA cell cohorts, IQCF3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IQCF3-associated genes across cancer lineages are OR1E2, OR1E3, and TMCO5A. Each is linked with IQCF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCF3-to-partner and partner-to-IQCF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E2 grouped by IQCF3-low versus IQCF3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCF3→partner) and Y-score (partner→IQCF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1E2 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1E3 →	+0.023	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1E2 by IQCF3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →