Across TCGA pan-cancer cohorts, IQCF2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IQCF2 data layer compared with 12 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher IQCF2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IQCF2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LGG and SKCM are the cancer types where IQCF2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.238	0.810	<.001	12	view →
SKCM	DFS	Median	II,III,IV	1.000	0.221	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IQCF2 tumor-vs-normal RNA expression · all IQCF2 data types