IQCF1

Across TCGA patient cohorts, IQCF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,961 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IQCF1-associated GO terms across cancer lineages are Maturation of 5.8S rRNA, tRNA metabolic process, and Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with IQCF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both IQCF1-to-partner and partner-to-IQCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA grouped by IQCF1-low versus IQCF1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCF1→partner) and Y-score (partner→IQCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Maturation of 5.8S rRNA →	+0.062	+0.160	<.001	<.001	3	20
STAD	tRNA metabolic process →	+0.052	+0.170	<.001	<.001	3	20
STAD	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.057	+0.153	<.001	<.001	3	19
STAD	RNA modification →	+0.048	+0.140	<.001	<.001	3	19
STAD	Regulation of DNA replication →	+0.053	+0.154	<.001	<.001	3	19
STAD	Regulation of DNA repair →	+0.051	+0.179	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,961 associations by consensus.

Maturation of 5.8S rRNA by IQCF1 expression — STAD

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