IQCF1

Across TCGA patient cohorts, IQCF1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCF1-associated genes across cancer lineages are Notch1, eEF2, and EGFR_pY1068. Each is linked with IQCF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCF1-to-partner and partner-to-IQCF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by IQCF1-low versus IQCF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCF1→partner) and Y-score (partner→IQCF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Notch1 →	-0.248	-3.000	.024	.036	3	1
UCEC	eEF2 →	+0.529	+2.321	.003	.035	3	1
UCEC	EGFR_pY1068 →	-0.335	-3.459	.007	.005	3	1
UCEC	INPP4B →	-0.362	-2.308	.025	.036	3	1
UCEC	Rab25 →	-0.374	-2.321	.024	.035	3	1
UCEC	Annexin-1 →	+0.558	+2.321	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by IQCF1 expression — SKCM

Explore this box plot interactively →