IQCE

Across TCGA pan-cancer cohorts, IQCE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IQCE data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IQCE mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IQCE expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where IQCE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.941	0.202	.038	13	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.889	.010	7	view →
CCRCC	DFS	Tertile	II,III,IV	0.777	0.226	.018	6	view →
PDAC	DFS	Quartile	All	0.372	0.843	.024	6	view →
GBM	DFS	Tertile	All	0.417	0.286	.030	2	view →
LUAD	OS	Median	III,IV	1.000	0.696	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IQCE–LSCC (DFS)

Open the LSCC breakdown →