IQCE

Across TCGA patient cohorts, IQCE mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCE-associated genes across cancer lineages are INPP4B, JNK2, and Notch1. Each is linked with IQCE in more than 3 cancer types. Because this analysis shows association rather than direction, both IQCE-to-partner and partner-to-IQCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by IQCE-low versus IQCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCE→partner) and Y-score (partner→IQCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.242	-2.906	.030	.001	3	2
UCEC	JNK2 →	+0.221	+1.736	.001	.007	3	2
COAD	Notch1 →	+0.195	+3.008	.042	.019	1	4
UCEC	ATM →	-0.358	-2.000	.023	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.800	+1.584	<.001	.032	3	2
COAD	ASNS →	+0.894	+3.008	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

INPP4B by IQCE expression — UCEC

Explore this box plot interactively →