IQCA1

Across TCGA patient cohorts, IQCA1 mutation is significantly associated with the RNA expression of many other genes, with 5,223 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCA1-associated genes across cancer lineages are RN7SL861P, TMED7-TICAM2, and CDC7. Each is linked with IQCA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IQCA1-to-partner and partner-to-IQCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL861P grouped by IQCA1-low versus IQCA1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCA1→partner) and Y-score (partner→IQCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL861P →	+0.345	+4.724	<.001	.003	3	3
COAD	TMED7-TICAM2 →	+0.251	+3.590	<.001	.001	3	3
UCEC	CDC7 →	+0.610	+1.551	<.001	<.001	3	3
UCEC	PIGH →	+0.302	+2.102	.005	<.001	3	3
UCEC	SNW1 →	+0.339	+1.743	.004	<.001	3	3
UCEC	LACTB →	+0.409	+2.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,223 associations by consensus.

RN7SL861P by IQCA1 expression — READ

Explore this box plot interactively →