IQCA1

Across TCGA patient cohorts, IQCA1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQCA1-associated genes across cancer lineages are 14-3-3_beta, ATM, and Cyclin-B1. Each is linked with IQCA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IQCA1-to-partner and partner-to-IQCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IQCA1-low versus IQCA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCA1→partner) and Y-score (partner→IQCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.087	-1.738	.003	.011	3	3
COAD	ATM →	-0.464	-3.000	.011	.035	3	3
UCEC	Cyclin-B1 →	+0.678	+3.087	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.240	-2.502	.001	.001	3	2
COAD	JNK2 →	+0.192	+2.178	.027	.035	3	2
UCEC	Ku80 →	+0.164	+1.197	.019	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

14-3-3_beta by IQCA1 expression — UCEC

Explore this box plot interactively →