IQCA1

Across TCGA cell cohorts, IQCA1 mutation is significantly associated with the RNA expression of many other genes, with 228 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQCA1-associated genes across cancer lineages are SLC5A8, DPPA4, and TREH. Each is linked with IQCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQCA1-to-partner and partner-to-IQCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A8 grouped by IQCA1-low versus IQCA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCA1→partner) and Y-score (partner→IQCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	2
OESOPHAGUS	DPPA4 →	+0.011	+4.017	.005	.007	3	1
BLOOD_Myeloma	TREH →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2AJ1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	NKAIN3 →	+0.023	+4.807	<.001	.006	3	1
OVARY	NPSR1 →	+0.034	+3.772	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

SLC5A8 by IQCA1 expression — BLOOD_Leukemia

Explore this box plot interactively →