Across TCGA pan-cancer cohorts, IPPKP1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IPPKP1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where IPPKP1 RNA is repressed in tumor relative to normal tissue. In most cancer types IPPKP1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and LUSC are the cancer types where IPPKP1 tumor–normal differential expression is most reproducible.