IPPK

Across TCGA pan-cancer cohorts, IPPK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IPPK data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IPPK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IPPK expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where IPPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.990	0.882	.003	24	view →
LSCC	OS	Median	All	0.529	0.925	.002	14	view →
GBM	DFS	Quartile	All	0.913	0.377	.002	6	view →
UCEC	DFS	Quartile	All	1.000	0.720	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IPPK–HNSC (DFS)

Open the HNSC breakdown →