IPPK

Across TCGA patient cohorts, IPPK mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPPK-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and MEK1. Each is linked with IPPK in more than 1 cancer types. Because this analysis shows association rather than direction, both IPPK-to-partner and partner-to-IPPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by IPPK-low versus IPPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPPK→partner) and Y-score (partner→IPPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.205	+3.000	.003	.036	3	2
UCEC	EGFR_pY1068 →	-0.297	-2.459	.014	.020	3	1
UCEC	MEK1 →	+0.410	+2.459	.020	.020	3	1
UCEC	STAT3_pY705 →	-0.509	-2.459	<.001	.020	3	1
UCEC	VHL →	-1.349	-3.321	<.001	.010	3	1
UCEC	ATM →	-0.447	-3.000	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C-Raf by IPPK expression — UCEC

Explore this box plot interactively →