IPPK

Across TCGA cell cohorts, IPPK mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IPPK-associated genes across cancer lineages are STRA8, PRSS37, and TEX46. Each is linked with IPPK in more than 1 cancer types. Because this analysis shows association rather than direction, both IPPK-to-partner and partner-to-IPPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STRA8 grouped by IPPK-low versus IPPK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPPK→partner) and Y-score (partner→IPPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	STRA8 →	+0.078	+3.415	.003	.001	3	1
LARGE_INTESTINE	PRSS37 →	+0.090	+3.302	<.001	.008	3	1
LARGE_INTESTINE	TEX46 →	+0.194	+3.497	<.001	.004	3	1
LARGE_INTESTINE	SMIM33 →	+0.686	+3.417	<.001	.004	3	1
BLOOD_Leukemia	C20orf85 →	+0.032	+5.969	<.001	.001	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

STRA8 by IPPK expression — LARGE_INTESTINE

Explore this box plot interactively →