Across TCGA patient cohorts, IPP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPP-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and EGFR_pY1068. Each is linked with IPP in more than 1 cancer types. Because this analysis shows association rather than direction, both IPP-to-partner and partner-to-IPP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPP→partner) and Y-score (partner→IPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.707	+2.019	.006	.017	3	2
UCEC	C-Raf →	+0.181	+3.321	.003	.010	3	2
UCEC	EGFR_pY1068 →	-0.264	-3.321	.015	.010	3	1
UCEC	A-Raf_pS299 →	-0.135	-2.459	.009	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-3.584	.003	.002	3	1
UCEC	Annexin-1 →	+0.652	+3.189	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

IPP survival (RNA) · tumor vs normal (RNA) · all IPP data types