Across TCGA patient cohorts, IPO9 mutation is significantly associated with the RNA expression of many other genes, with 2,935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO9-associated genes across cancer lineages are NUP43, ZWINT, and PIMREG. Each is linked with IPO9 in more than 3 cancer types. Because this analysis shows association rather than direction, both IPO9-to-partner and partner-to-IPO9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO9→partner) and Y-score (partner→IPO9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUP43 →	+0.377	+1.709	<.001	<.001	3	4
UCEC	ZWINT →	+0.550	+1.818	.001	.003	3	4
UCEC	PIMREG →	+0.562	+1.709	.003	<.001	3	4
COAD	CDCA8 →	+0.613	+3.210	<.001	.009	3	4
UCEC	CENPO →	+0.399	+2.010	.002	.005	3	4
UCEC	CCNA2 →	+0.686	+1.917	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,935 associations by consensus.

Exploration

IPO9 survival (RNA) · tumor vs normal (RNA) · all IPO9 data types