Across TCGA cell cohorts, IPO9 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO9-associated genes across cancer lineages are CGB2, APOC3, and NXPH1. Each is linked with IPO9 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO9-to-partner and partner-to-IPO9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO9→partner) and Y-score (partner→IPO9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CGB2 →	+0.875	+3.234	<.001	.008	3	1
BLOOD_Leukemia	APOC3 →	+0.259	+3.475	<.001	.006	3	1
BLOOD_Leukemia	NXPH1 →	+0.336	+3.884	<.001	.003	3	1
BLOOD_Leukemia	HABP2 →	+0.451	+4.007	<.001	.002	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.475	<.001	.006	3	1
BLOOD_Leukemia	LYZL4 →	+0.040	+3.567	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

Exploration

IPO9 survival (RNA) · tumor vs normal (RNA) · all IPO9 data types