Across TCGA patient cohorts, IPO7 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO7-associated genes across cancer lineages are MEK1, p90 RSK_pT359_S363, and PDCD4. Each is linked with IPO7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO7-to-partner and partner-to-IPO7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO7→partner) and Y-score (partner→IPO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.502	+2.392	<.001	<.001	3	2
UCEC	p90 RSK_pT359_S363 →	-0.218	-2.807	.002	.002	3	2
UCEC	PDCD4 →	-0.572	-1.990	<.001	.009	3	2
UCEC	RBM15 →	+0.252	+3.335	.025	.005	3	2
UCEC	ASNS →	+0.394	+1.678	.002	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.579	+2.341	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

IPO7 survival (RNA) · tumor vs normal (RNA) · all IPO7 data types