Across TCGA cell cohorts, IPO7 mutation is significantly associated with the protein abundance of many other proteins, with 36 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IPO7-associated proteins across cancer lineages are HDGFL2, SRRM2, and BOLA2B. Each is linked with IPO7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO7-to-partner and partner-to-IPO7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO7→partner) and Y-score (partner→IPO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HDGFL2 →	+0.425	+3.206	.002	.006	3	1
BLOOD_Leukemia	SRRM2 →	+0.378	+3.352	.003	.004	3	1
BLOOD_Leukemia	BOLA2B →	+0.619	+3.206	.001	.006	3	1
BLOOD_Leukemia	BOLA2 →	+0.619	+3.206	.001	.006	3	1
BLOOD_Leukemia	XPNPEP3 →	+0.675	+3.279	.009	.005	3	1
BLOOD_Leukemia	ARFGAP3 →	+0.679	+3.169	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

IPO7 survival (RNA) · tumor vs normal (RNA) · all IPO7 data types