IPO5

Across TCGA patient cohorts, IPO5 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO5-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and ACVRL1. Each is linked with IPO5 in more than 2 cancer types. Because this analysis shows association rather than direction, both IPO5-to-partner and partner-to-IPO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by IPO5-low versus IPO5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO5→partner) and Y-score (partner→IPO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.317	-1.584	.037	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.765	+2.189	<.001	.001	3	3
SKCM	ACVRL1 →	+0.136	+2.502	.012	.001	3	2
UCEC	Annexin-1 →	+0.523	+2.434	.002	.001	3	2
SKCM	TAZ →	+0.153	+2.186	.013	.032	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.364	-2.000	.015	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by IPO5 expression — UCEC

Explore this box plot interactively →