IPO5

Across TCGA cell cohorts, IPO5 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IPO5-associated genes across cancer lineages are CABP5, OR9K2, and GAGE12F. Each is linked with IPO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IPO5-to-partner and partner-to-IPO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by IPO5-low versus IPO5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO5→partner) and Y-score (partner→IPO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR9K2 →	+0.023	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	GAGE12F →	+1.063	+5.209	<.001	.005	3	1
BLOOD_Leukemia	DIO3 →	+0.249	+3.934	<.001	.005	3	1
BLOOD_Leukemia	USP17L4 →	+0.033	+4.269	<.001	.002	3	1
BLOOD_Leukemia	USP17L8 →	+0.003	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

CABP5 by IPO5 expression — BLOOD_Lymphoma

Explore this box plot interactively →