Across TCGA patient cohorts, IPO4 mutation is significantly associated with the RNA expression of many other genes, with 2,033 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO4-associated genes across cancer lineages are C5orf22, MIR4760, and RN7SKP190. Each is linked with IPO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IPO4-to-partner and partner-to-IPO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO4→partner) and Y-score (partner→IPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C5orf22 →	+0.411	+1.676	.004	.003	3	3
LGG	MIR4760 →	+0.841	+5.679	<.001	.003	3	3
KIRC	RN7SKP190 →	+0.129	+5.316	.005	.006	3	3
UCEC	IGSF22 →	-0.264	-1.837	.001	.007	3	3
UCEC	MND1 →	+0.706	+2.273	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.557	+1.765	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,033 associations by consensus.

Exploration

IPO4 survival (RNA) · tumor vs normal (RNA) · all IPO4 data types