Across TCGA patient cohorts, IPO4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IPO4-associated genes across cancer lineages are Bak, Caspase-7-cleavedD198, and eIF4E. Each is linked with IPO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IPO4-to-partner and partner-to-IPO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO4→partner) and Y-score (partner→IPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.200	+1.523	.012	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.546	+2.107	.003	.002	3	3
UCEC	eIF4E →	+0.171	+1.777	.011	.002	3	2
UCEC	Ku80 →	+0.224	+1.820	.002	.014	3	2
UCEC	p62 Lck ligand →	+0.462	+2.378	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.364	+1.807	.005	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

IPO4 survival (RNA) · tumor vs normal (RNA) · all IPO4 data types