IPO4

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, IPO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,353 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IPO4-associated GO terms across cancer lineages are Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA 5'-end processing, and Regulation of transcription by RNA polymerase I. Each is linked with IPO4 in more than 18 cancer types. Because this analysis shows association rather than direction, both IPO4-to-partner and partner-to-IPO4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IPO4→partner) and Y-score (partner→IPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BONEEndonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →+0.180+1.243<.001<.001319
BONErRNA 5'-end processing →+0.180+1.243<.001<.001319
BONERegulation of transcription by RNA polymerase I →+0.114+0.665<.001.005319
BONEEndonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →+0.161+1.390<.001<.001318
BONEMaturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →+0.141+1.141<.001<.001318
BONEEndonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →+0.156+1.238<.001<.001318
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,353 associations by consensus.

Exploration